Introducing PDRN Microneedling
- Crystal Canela
- Sep 12
- 5 min read
In the ever-evolving world of skincare, new treatments and technologies emerge regularly, promising to rejuvenate and revitalize our skin. One such treatment that has gained significant attention in recent years is PDRN microneedling. This innovative procedure combines the benefits of microneedling with the regenerative properties of PDRN (Polydeoxyribonucleotide), a compound derived from salmon DNA. In this blog post, we will explore the benefits of PDRN microneedling, delve into clinical studies that support its efficacy, highlight celebrities that support this ingredient, discuss its growing popularity, and provide insights into the cost of this treatment.
1. Introduction: What Is PDRN Microneedling?
PDRN stands for Polydeoxyribonucleotide, a compound derived from purified fragments of DNA (most commonly sourced from salmon sperm because its DNA structure is highly compatible with human DNA).
It was originally developed in the medical field for tissue repair and wound healing, and over the years, research has expanded its use into cosmetic dermatology for skin rejuvenation.
Microneedling is a minimally invasive cosmetic procedure that creates controlled micro-injuries in the skin, prompting collagen and elastin production and resulting in smoother, firmer skin.
When combined, microneedling acts as a delivery mechanism for PDRN, allowing deeper penetration into the dermis for more potent rejuvenation effects.
Cosmetic Benefits of PDRN
When applied with treatments like microneedling, mesotherapy, or topical boosters, PDRN supports:
Collagen & Elastin Production → tighter, firmer, and more youthful skin.
Skin Repair & Renewal → reduces acne scarring, fine lines, and sun damage.
Hydration & Elasticity → strengthens the skin barrier, giving a plumper appearance.
Even Skin Tone → helps fade pigmentation and discoloration.
Anti-Inflammatory Action → calms sensitive or reactive skin (beneficial for rosacea-prone skin).
Overall Rejuvenation → restores skin’s vitality and radiance.
What is PDRN Microneedling?
PDRN microneedling is a minimally invasive cosmetic procedure that involves the use of fine needles to create micro-injuries in the skin. This process stimulates the body’s natural healing response, promoting collagen and elastin production. When combined with PDRN, the treatment enhances skin rejuvenation by delivering growth factors directly into the dermis, which helps to repair and regenerate skin cells.
The PDRN used in this esthetic practice- Skin Palace & Wellness- is known for its ability to accelerate wound healing and improve skin texture. It is rich in nucleotides, which are essential for cellular repair and regeneration. As a result, PDRN microneedling not only addresses common skin concerns such as fine lines, wrinkles, and uneven skin tone but also promotes overall skin health.
Clinical Studies Supporting PDRN Microneedling
Numerous clinical studies have been conducted to evaluate the effectiveness of PDRN microneedling in skin rejuvenation. One notable study published in the Journal of Cosmetic Dermatology found that patients who underwent PDRN microneedling experienced significant improvements in skin elasticity, hydration, and overall texture compared to those who received traditional microneedling without PDRN.
Another study published in the International Journal of Dermatology demonstrated that PDRN microneedling effectively reduced the appearance of acne scars and improved skin tone in participants. The researchers concluded that the combination of microneedling and PDRN significantly enhances the skin's regenerative capabilities, leading to more noticeable and longer-lasting results.
These studies highlight the potential of PDRN microneedling as a powerful tool in the realm of skincare, providing evidence that supports its growing popularity among both practitioners and patients.
Celebrities love PDRN!
Celebrities such as Lindsay Lohan, Hailey Bieber, Kim Kardashian, Kylie Jenner, and Kendall Jenner are known to use and have publicly endorsed PDRN-infused skincare products and treatments for their skin-regenerating, hydrating, and complexion-boosting properties. Other celebrities like Jennifer Aniston and Miley Cyrus have also been noted for their use of PDRN skincare, often through salmon DNA facials and microneedling.
As of June 2025 we have introduced many of our clients to our newest Signature Facial which includes high quality PDRN. This new signature facial includes microcurrent technology which we like to call 'Pilates for the face', a strong focus on lymphatic facial & neck massage and in combination with active ingredients like Vitamin C, Hyaluronic Acid & PDRN (Polydeoxyribonucleotide) we have created the perfect "maintenance" facial!
This facial was one of the many treatments used during my weight loss and postpartum journey to eliminate sagging (during weight loss), dull and dehydrated skin (due to lack of self care time) and regain my overall youthful glow back! Several clients started noticing and asking what I was using- so it only made sense to make it my signature facial which has been our top service this summer! We have also brought in new products which all contain PDRN.
Why PDRN Is Growing in Popularity
✨ Science-Backed Results PDRN isn’t just a trendy ingredient—it has published studies behind it. Research shows it helps stimulate fibroblasts (the cells that make collagen), improve wound healing, boost blood circulation, and even reduce pigmentation. This gives it credibility that savvy clients and providers are looking for.
✨ Dual Action: Healing + Anti-Aging Unlike fillers or Botox, which target a single concern, PDRN works at a deeper, regenerative level. It helps repair damaged tissue while improving fine lines, skin texture, and overall radiance. Clients love that it doesn’t just cover up aging—it encourages the skin to heal itself.
✨ Versatility in Treatments It pairs beautifully with microneedling, post laser resurfacing, PRP, and other in-office procedures. Some clinics also use it as a stand-alone injectable “skin booster” although it is only FDA approved in the states to be used topically, you can fly to Korea like Kim Kardashian did and get it injected into your face AND microneedled at the same time- a lot yes we know- that's why we only recommend using it along side microneedling!
✨ Results Clients Notice People report smoother skin, smaller pores, improved elasticity, faster recovery after aggressive treatments, and even more even tone. The visible results after just a few sessions create buzz and drive word-of-mouth growth.
✨ Part of the “Regenerative Aesthetics” Movement The aesthetics industry is shifting from simply “filling and freezing” to therapies that actually regenerate tissue (like stem cells, exosomes, PRP). PDRN fits perfectly into this new philosophy of bio-stimulation and long-term skin health.
👉 In short: PDRN is trending because it bridges science and beauty—offering clinical credibility, natural repair mechanisms, and cosmetic results that patients can see and feel.
Cost of treatments
In major cities like NYC and LA, this trending treatment can cost up to $800 per session. At Skin Palace, we believe advanced skincare should be accessible—not exclusive—so everyone can enjoy the benefits. That’s why we’re offering a special introductory treatment for just $200, or $750 for a package of three for a limited time. Each package also includes a PDRN post-care kit and two dermaplaning treatments to enhance your results.
✨ See our Plans & Pricing page for full details, and click here to take advantage of this limited-time offer!
In conclusion...
PDRN microneedling isn’t just another trend—it’s a regenerative treatment with science-backed benefits and growing worldwide recognition. If you’re looking for a natural, effective way to restore your skin’s health and radiance, this innovative therapy may be exactly what you’ve been waiting for. At Skin Palace, we’re proud to bring you the same advanced treatments that celebrities and skincare experts rave about—without the sky-high price tag. Ready to see what all the buzz is about? Book your PDRN microneedling session today and discover the future of skin rejuvenation.
Comments